Androgenic Steroids And Testosterone
Nonphysician prescribed, off-the-shelf, and self-induced testosterone and androgenic steroids have numerous negative health effects on lipids, testicular biopsy, and serum chemistry. Lipids are primarily responsible for the storage and maintenance of low density lipoproteins (LDL) in the bloodstream. High density lipoproteins (HDL) are primarily responsible for the transport of cholesterol to and from arterial walls. Both steroids and fat cells accelerate fat accumulation and, consequently, increase cardiovascular risk. Testosterone and androgens increase the growth of abnormal cells in the prostate, adrenal gland, colon, pancreas, and thyroid gland and decrease the synthesis of the hormone. The effects of self-induced androgenic steroids on plasma testosterone, triglyceride, and cholesterol levels were studied in 14 normal men, 10 body builders and 3 strength-trained men with known liver disease.
Testosterone and androgens stimulate the production of inflammatory mediators, enhance proliferation of malignancies, cause enlargement of benign tumors, cause inflammation of the prostate and bladder, increase testicular biopsy, and increase leptospirosis. The effects of testosterone and androgenic steroid use and abuse on cardiovascular disease (CVD), homocysteine levels, and stroke are unknown. Testosterone replacement therapy with hydroxychloroquine and cisplatin increased homocysteine levels and decreased plasma HDL levels in patients with previous myocardial infarction (MIA). Clinical trials are currently underway to investigate the causal relationship between testosterone therapy and potentially fatal coronary artery disease.
Women with low testosterone levels muscleroids.com/ due to congenital adrenal hyperplasia (CAH) or women undergoing hormonal replacement therapy for cancer are at elevated risk of all-cause mortality, cardiovascular disease, and breast cancer. Low testosterone concentrations are believed to contribute to liposuction complications, which in turn may lead to stroke. In addition, women with CAH or women taking hormonal medications that alter the normal function of aromatase (Aromatase is an enzyme in the body that converts testosterone into estrogen) are at increased risk of fractures. Furthermore, women with low testosterone levels are at increased risk of various kinds of prostate cancer including prostatic intraepithelial neoplasia, transitional cell carcinoma, and squamous cell carcinoma. Researchers believe these findings are primarily due to the influence of testosterone and androsterone on the prostate tumor cells.
Testosterone and androstenedione, a product of the androgen metabolism, cause the formation of benign tumors. These tumors, called micrometastasis, can occur in the bladder, kidney, pancreas, prostate, or esophagus. The hormone androstenedione causes the conversion of testosterone into estrogen. This process can accelerate the development of micrometastasis in tissues that produce estrogen. Therefore, men with androgeneital tumors appear to be more likely to be predisposed to cardiovascular disease.
A common question among androgenic steroid users is, can you use testosterone with androsterone? The short answer to this question is yes, you can! However, there was one study showing that men who used oral testosterone with androsterone had a higher incidence of testicular cancer. The study was conducted by investigators from the National Institute of Diabetes and Digestive and Kidney Diseases; the National Institute of Arthritis and Musculoskeletal Disease; and the National Institute of Health. The study was published in the journal Fertility and Sterility.
Some medical experts recommend testosterone therapy for young men who cannot conceive. Doctors also recommend testosterone therapy if a patient has not responded well to non testosterone treatments like spironolactone or clomiphene citrate. However, the use of steroids in men has become controversial because some studies have shown that these drugs increase the risk of prostate cancer. Men with advanced prostate disease should not use these drugs because they can cause neoplastic changes in the prostate. Studies also show that long term androgenic steroid use may lead to cataracts, bone deterioration and vision loss. For this reason, patients should have their eyes tested regularly.